Each set has six runes. Equipping more pieces of one set unlocks its bonuses at 2, 4 and 6.
Warrior
Strong Shield of the Atheron

+10% Critical Hit Chance.
Critical Hit heals 5% of Max Health.
Rage Shield provides an additional 20% Critical Hit Chance and 50% Critical Hit Damage.
Eye of the Storm

+50% Physical Damage.
Whirlwind strikes and spins 25% faster and lasts 3 seconds longer.
While channeling Whirlwind, all Special abilities can be cast in addition to Warcry abilities.
Weight of the Mountain

+100% Special Ability Damage.
Each Basic Attack cast reduces Earthstrike's cooldown by 0.8 seconds.
Harvest Moon

+50% Strong Attack Damage.
Each enemy struck by Half Moon Slash grants a stack of Crescent Momentum for 3 seconds, up to 20 stacks. Each stack grants +1 Mana Regeneration and +1% Critical Hit Chance.
Half Moon Slash's blades no longer fly past. They hunt the enemies around where you aimed for 3 seconds.
Sorcerer
Infernal Covenant

Frozen Barrage

+65% Damage to Slowed enemies.
+60% Attack Speed. Ice Shards also applies Chill.
Ice Shards fires 4 additional projectiles. Each projectile can pierce through 1 target.
Stormcaller

+50% Lightning Damage.
Each Lightning Storm strike deals splash damage.
Each Lightning Storm strike creates a Lightning Ball that pulses 3 times at 0.75-second intervals, each dealing 75% weapon damage as Lightning damage in a small radius.
Hunter
Trapper's Legacy

Direct damage from traps increased by 60%.
Enemies hit by your traps receive your Death Mark for 3.5 seconds, granting you +30% Critical Chance against them.
Traps can be retriggered 3 additional times.
Deadeye's Resolve

Physical damage increased by 50%.
While channeling Rapid Fire, gain 25% damage reduction.
Your deadeye focus sharpens. Rapid Fire shoots 30% faster, deals double damage, and its arrows now pierce up to 3 targets.
Venomfang

Damage against poisoned enemies increased by 70%.
Applying poison reduces the target's movement speed by 25% and attack speed by 20% for 5 seconds. Reapplying poison refreshes the slow.
Casting Poison Shot has a 50% chance to launch an arcing venom projectile that deals 420% weapon damage as Poison in a small area and applies 2 stacks of poison to all enemies hit.
Monk
Hundred Hands

+100% Basic Attack Damage.
Each stack of Furious Fist also grants +3% Physical Damage, up to +60% at 20 stacks.
Your Furious Fist has a 25% chance to unleash Golden Palms for free, without knockback. These Golden Palms inflict Dazed and deal 0.5% more damage per point of current Mana.
Wheel of Nine Heavens

+100% Special Ability Damage.
Sacred Orbs conjures one additional orb.
When a Sacred Orb's time runs out it no longer fades. It breaks orbit, streaks to the nearest enemy and bursts for 300% weapon damage as Lightning damage in a 3m radius.
Serpent's Tongue

+50% Strong Attack Damage.
Piercing Lunge costs half as much Mana.
Piercing Lunge's airflow pierces through enemies behind the target, inflicting Vulnerable. Each cast also reduces the remaining cooldown of a random Special ability by 1 second.